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Purpose
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A potent microtubule polymerization inhibitor
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Characteristics
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ABT751 is a potent inhibitor of microtubule polymerization. It binds to the colchicine- on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.
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Purity
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≥ 98?% by HPLC
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Chemical Name
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N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide
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Formula
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C??H??N?O?S
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Permeability
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Cell-permeable
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Solubility
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DMSO (>30 mg/ml) or EtOH (>5 mg/ml)
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