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  • 產(chǎn)品名稱(chēng)：Mouseanti-HumanIgGAntibody

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  • 產(chǎn)品廠商：Biossusa
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Mouseanti-HumanIgGAntibody
詳情介紹：
Immunogen Protein purified from Human plasma
Clone 3E8
Isotype IgG1 kappa
Purification Purified by Protein G.
Background

Immunoglobulin G (IgG) is a monomeric immunoglobulin, built of two heavy chains γ and two light chains. Each molecule has two antigen s. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids. This is the only isotype that can pass through the placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66?% ), IgG2 (23?%), IgG3 (7?%) and IgG4 (4?%). 1) IgG1, IgG3 and IgG4 cross the placenta easily. 2) IgG3 is the most effective complement activator and IgG4 does not activate complement. 3) IgG1 and IgG3 bind with high affinity to Fc receptors on phagocytic cells. IgG4 has intermediate affinity and IgG2 affinity is extremely low.
UniProt P01857
Research Area Immunology, Secondary Antibodies
Application Notes WB(0.1?μg/mL)
IP(1.0?μg)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer HEPES with 0.15M NaCl, 0.01?% BSA, 0.03?% sodium azide, and 50?% glycerol. Store for 1 year at -20?°C from date of shipment.
Storage -20 °C
Storage Comment HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Store for 1 year at -20°C from date of shipment.