產(chǎn)品詳情
簡單介紹:
AktInhibitor,Isozyme-Selective
詳情介紹:
Purpose | An Akt inhibitor (Isozyme-Selective) |
Characteristics | A potent and selective inhibitor of Akt1/Akt2 activity (IC50 = 58 nM (Akt1), 210 nM (Akt2) and 2.12 μM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 μM). |
Purity | ≥ 97?% by HPLC |
Chemical Name | 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2 |
Formula | C??H??N?O |
Permeability | Cell-permeable |
Solubility | DMSO |
Molecular Weight | 551.65 g/mol |
CAS-No | 612847-09-3 |
Restrictions | For Research Use only |
Format | Solid |
Handling Advice | Protect from air and moisture |
Storage | -20 °C |
Expiry Date | 24 months |
Supplier Images |
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