Immunogen
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Native Protein IgA Immunoglobulin A (IgA) is an antibody that plays a critical role in mucosal immunity. More IgA is produced in mucosal linings than all other types of antibody combined. IgA has two subclasses (IgA1 and IgA2) and can exist in a dimeric form called secretory IgA (sIgA). In its secretory form, IgA is the main Immunoglobulin found in mucous secretions, including tears, saliva, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. The secretory component of sIgA protects the Immunoglobulin from being degraded by proteolytic enzymes, and can also inhibit inflammatory effects of other Immunoglobulins. IgA is a poor activator of the complement system, and opsonises only weakly. The antibody is a rabbit polyclonal antibody raised against IgA.
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